Bioinformatics Solutions Inc.

Disruption of protein synthesis can be a useful therapeutic target in conditions where excessive or aberrant protein production contributes to disease, like cancer and viral infections. Current pharmaceuticals that can inhibit protein translation are being tested in clinical trials, including the class of drugs known as rocaglates. However the system-wide effects of these drugs are poorly understood and need to be further investigated. In a recent study by Ho and colleagues, ...researchers used LC-MS/MS to examine the influence of a rocaglate on the cellular proteome and translatome to determine how far reaching the effects of these drugs are on the process of protein production. The study used a powerful combination of chemical labelling, at both the protein and peptide level, as well as organelle enrichment to interrogate specific cellular responses to this potentially important class of drugs, showing that their effects go far beyond the initial stages of connecting the instructions to the machinery. Learn more on how this cross-disciplinary collaboration combines advanced techniques in cellular biology with expertise in mass spectrometry to capture the translational landscape during a highly important cellular events. https://www.bioinfor.com/proteomics-reveal-cap-dependent-t/ #proteomics #scientificresearch #massspectrometry #bioinformatics #oncology #clinicalresearch #therapeutictarget #cellbiology #lifescience #medicine #research #collaboration

We hope you are excited to hear Cristina Clement Ph.D. speak at our PEAKS Users' Meeting tomorrow! As the Assistant Prof. in Radiation/Oncology at Weill Cornell Medicine, Dr. Clement focuses on mechanisms changing processing and presentation of antigens in peptidomes/proteomes in dendritic cells and will be sharing some of her latest work. #oncology #proteomics #massspectrometry #asms2021

Need results fast? Due dates and funding deadlines can sneak up on you. Let our team help you hit your targets! BSI Antibody Sequencing Service can turn your mAb sample into an antibody sequence in as little as 1-2 weeks, with full de novo coverage of the entire variable region with at least 98% confidence at each individual amino acid. Expect better, faster with BSI! Learn more about our strategies to sequencing antibodies, and contact our team for a free consultation, [email protected] https://www.bioinfor.com/antibodyservice/ #contractresearchorganization #laboratory #antibodysequencing #antibodydiscovery #sequencevalidation #dataanalysis #aminoacid #bioinformatics #massspectrometry #methodology #proteinengineering #proteinsequencing #biotechnology #antibodies #biopharmaceuticals See more

Neuropeptides are a diverse class of molecules, with a wide range of physiological effects, making them an interesting target to study. Biologically they are produced as inactive prepropeptides that can contain one or more copies of the active peptide, as well as signal sequences, cleavage sites, and spacer regions. Due to this unique composition and low in vivo concentration, they present a challenge to researchers wanting to examine these molecules using LC-MS/MS. One str...ategy, which was recently used by Realis-Doyelle and colleagues, is to focus on a specific tissue, in this case visceral ganglia, and conduct a transcriptomic survey of this tissue and advanced MS methods that maximise identification of low abundance peptides. This study incorporates trapped ion mobility separation to time-of-flight (tims-TOF) mass analysis with parallel accumulation serial fragmentation (PASEF) technology. These technologies are powerful methods that produce complex datasets, however the use of PEAKS platforms, including PEAKS Studio or PEAKS Online, that have ion mobility integration allowed the researchers to account for the additional dimension in the data. This work provides an overview of the neuropeptide precursors (NPPs)/peptide precursors (PPs) expressed in oyster C. gigas, with the characterization of 44 new NPPs. Learn more about their approach and how better knowledge of regulators underlying reproduction may also prove valuable for the most important aquaculture shellfish worldwide. https://www.bioinfor.com/transcriptome-profiling-of-the-pa/ #biology #lifesciences #signalingpathways #mechanism #bioinformatics #massspectrometry #proteomics #neuropeptides #aquaculture #research

Grab a drink on us! Join us virtually on October 28th for our 2021 PEAKS Users' Meeting Happy Hour with special guests, Dr. Cristina C. Clement (Weill Cornell Medicine), Dr. Andy Y. Qi (NIH/NIA) and Prof. Dr. Anthony Purcell (Monash Uni)! Register here, https://www.bioinfor.com/peaks-users-meeting/