Biological Information Theory

Beginning with artificial strain Syn61of E.coli in which all of the serine codons TCG and TCA and the stop codon TAG had been replaced with synonymous codons, the authors created a derived strain in which they deleted the tRNAs and the release factor that decoded those codons. They then demonstrated how those codons could be reassigned to specific noncanonical amino acids by using "engineered mutually orthogonal aminoacyl-tRNA synthetase (aaRS)/tRNA pairs" that recognized and decoded distinct codons with distinct noncanonical amino acids.

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Nobel Prize Web Site Posting on Laureate Har Gobind Khorana

Nobel Prize Web Site Posting on Laureate Har Gobind Khorana

Our paper on restriction enzymes got published! https://doi.org/10.1371/journal.pone.0222419 More resources and a Layman's summary are at: https://alum.mit.edu/www/toms/papers/lattice/

https://vimeo.com/323615460

Noting the passing of Donald A.B. Lindberg, the influential leader of the National Library of Medicine and PubMed.